Gastric Cancer Stem Cells Effect on Th17/Treg Balance; A Bench to Beside Perspective
نویسندگان
چکیده
منابع مشابه
Gastric stem cells and gastric cancer stem cells
The gastric epithelium is continuously regenerated by gastric stem cells, which give rise to various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells, mucous neck cells, and enteroendocrine cells. The self-renewal and differentiation of gastric stem cells need delicate regulation to maintain the normal physiology of the stomach. Recently, it was hypothesized ...
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Intracellular reactive oxygen species (ROS) play an important role in cancer stem cell (CSC) function. Hesperetin (Hst) is a flavonoid that has been shown to affect cellular ROS level. The goal of this study was to investigate the effect of Hst on the level of ROS in gastric CSCs (GCSCs). MTT assay was used to evaluate cell survival. Cellular ROS level was measured using 2′,7′-dichlorofluoresci...
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Gastric cancer (GC) is one of the most common cancers worldwide. Among GC patients the mortality rate remains high-most are diagnosed at advanced disease stages due to the lack of symptoms in early disease. Prominent risk factors include age, male sex, smoking, radiation, H. pylori colonization, and a positive family history. Depending on tumor staging, treatment consists of neoadjuvant, adjuva...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2019
ISSN: 2234-943X
DOI: 10.3389/fonc.2019.00226